In The News: School of Integrated Health Sciences

Drug Discovery News

In July 2022, a bombshell dropped on the Alzheimer's disease research field. For years, researchers had searched for something that caused the disease’s telltale amyloid plaques — complex tangles of a protein called amyloid-beta (Aβ) frequently found in the brains of patients with neurodegenerative disorders. A series of studies published starting in the mid-2000s reported the discovery of a toxic form of Aβ in the brains of mouse models of Alzheimer's disease called Aβ*56. Researchers hoped that Aβ*56 was the protein that snowballed into those amyloid plaques. But a team of sleuths found that many of the papers describing Aβ*56 were fraudulent and contained an array of faked images and blots. The fraud seemed to call the entire idea of amyloids causing Alzheimer’s disease into question.

Live Science

From sprinting to long distance, the body uses a lot of energy during running and eventually becomes fatigued. How often the feet hit the ground and at what angle can not only improve running efficiency, but potentially help prevent injury too. This is known as cadence — something that many of the best running watches now have the ability to track. But what cadence is best? And is it possible for someone to change their running cadence? We looked at the science.

Las Vegas Review Journal

A musical superstar has recruited a UNLV student for her effort to improve young people’s mental health. The Born This Way Foundation, co-founded in 2012 by Lady Gaga and her mother, Cynthia Germanotta, announced its new group of 31 advisory board members Tuesday, including Faria Tavacoli, a 20-year-old sophomore majoring in public health and minoring in neuroscience at UNLV.

Healthline

Gym-goers and athletes alike use many different compounds to help boost physical performance — from proteins to branched-chain amino acids. Another one that’s long been associated with improved exercise performance is dietary nitrate, a natural chemical that the body converts to nitric oxide. Research has shown it can improve muscle and cardiovascular function.

United Press International

Predicting when new drugs come to market in the United States has never been an exact science, and it has become even harder since the start of the COVID-19 pandemic, experts told UPI. But some drugs on the horizon have the potential to make a major impact.

Smithsonian Magazine

NASA is preparing to return astronauts to the lunar surface. And this time with more ambitious goals.

Supercluster

Those missions, which had a successful kickoff with Artemis-1, will establish the groundwork for months-long human habitation on the Lunar surface. Proposed base camps will present unique opportunities to test technology, unravel scientific secrets about the Moon's past and present, search for the presence of water, and more.

Alzheimer's News Today

AB Science is initiating a Phase 3 trial to evaluate the safety and efficacy of its candidate therapy masitinib in patients with mild to moderate Alzheimer’s disease.

Streetwise Reports

Biopharmaceutical company Axsome Therapeutics Inc. (AXSM:NASDAQ), which is focused on developing new medicines for use in the treatment of central nervous system (CNS) disorders, today announced that "AXS-05, a novel, oral, investigational NMDA receptor antagonist with multimodal activity, met the primary and key secondary endpoints in the ACCORD (Assessing Clinical Outcomes in Alzheimer's Disease Agitation) Phase 3 trial, by substantially and statistically significantly delaying the time to relapse and preventing relapse of agitation in patients with Alzheimer's disease, as compared to placebo."

Neurology Live

Newly announced findings from the phase 3 ACCORD trial (NCT04797715) showed that AXS-05 (Axsome Therapeutics), a novel, investigational n-methyl-D-aspartate (NMDA) receptor antagonist, met its primary end point of statistically significant delay in time to relapse and preventing relapse of agitation in patients with Alzheimer disease (AD) agitation.1

Women's Health

Diet trends go in and out of style, but intermittent fasting has been a buzzy diet among celebs for a while. Plenty of people swear by the health and weight loss benefits. Still, even the same weight-loss method can work differently from person to person, you may be wondering whether there is a best way to do intermittent fasting for women and get the most out of your efforts.

Healthline

A new study that is being presented this week at the American College of Cardiology Middle East 2022 Together With the 13th Emirates Cardiac Society Congress, reports that eating more refined grains was linked with a greater risk for premature coronary artery disease (PCAD).