Shopkeepers in Amalfi and Capri complain about day-trippers much like the folks who lament the invasion cruisers to their shores. They, too, arrive en masse on ferries or buses, spend minimally and clog the streets monumentally, especially at photogenic sites on influencers’ lists.

Over the past two years, Eisai and Biogen’s Leqembi and Eli Lilly’s Kisunla, both anti-amyloid antibodies, made history as the first real options to slow cognitive decline associated with Alzheimer’s disease. For years, amyloid plaques and tau tangles have been a primary target of Alzheimer’s disease research and drug development, but while affecting these proteins may yield some benefit, the illness continues to progress. Today, multiple therapeutics are in Phase III trials with other targets, suggesting that within the next few years it may become possible to treat Alzheimer’s via multiple pathways.

One of the greatest mysteries of the universe is the formation of the appropriately termed supermassive black holes, which can weigh up to a million times the mass of the sun and are found in the center of most galaxies.

AJ Pratt may be the Forrest Gump of organized crime. Or, possibly, its Sidd Finch — the Mets pitching prospect and French horn enthusiast George Plimpton invented for Sports Illustrated. The docuseries “The Tailor of Sin City” (10 p.m. Thursday, SundanceTV) follows Pratt as he builds a clothing business in Wichita, Kansas — then leaves it all behind in 1969 for a move to Las Vegas.

In Eastern philosophy, all entities in nature, including human beings, are made of three qualities or gunas: rajas (passion, activity, change, creation), sattva (goodness, harmony, purity, preservation), and tamas (darkness, chaos, inertia, destruction). In an apple tree, there are three kinds of fruits that denote these three gunas: there are ripening fruits (rajas), there are ripe fruits (sattva) and there are overripe fruits (tamas). In human beings, also there are people full of passion and energy (domination of rajas), people in harmony and purity (domination of sattva) and people who are lazy and full of inertia (domination of tamas).

Following the death of her son, a mom is warning others about the “blackout challenge” (also known as the “choking challenge”), a dangerous viral TikTok trend.

The giant black hole at the center of our galaxy has an unexpected spin, which is likely to be the result of a merger with another large black hole. The merger almost certainly occurred with the smaller, but still technically supermassive, black hole at the heart of a galaxy that was swallowed by the Milky Way.

The rising number of unhoused and the lack of affordable housing are problems that many cities and states struggle with. It’s not an issue that comes up a lot when politicians hit the campaign trail, maybe because it seems so difficult, and because it’s controversial.