Assistant professor Mo Weng (Life Sciences) was recently awarded CAREER: Molecular mechanisms of epithelial and mesenchymal plasticity: the reversible regulation of cell polarity and cell adhesion from the National Science Foundation (NSF). The proposal is to investigate the molecular mechanisms of epithelial-mesenchymal plasticity, a cellular process critical for generating cell diversity and promoting tumor malignancy, using multipronged approach including quantitative live imaging, genetics and optogenetics.

The proposed research will study a fundamental cellular process called epithelial-mesenchymal transition (EMT) which converts cells between the two basic cell states: epithelial and mesenchymal states. Epithelial cells, such as our skin and gut lining, form connected and stable barriers and framework of organs, while mesenchymal cells, such as muscle and blood cells, provide dynamics and mobility. EMT is crucial for generating diverse cell types during normal development. When misregulated, EMT is at the center of tumor malignancy by promoting processes such as metastasis. Recent advances have shifted the concept of EMT from a binary switch to a more fluid model: cells transition back and forth along an epithelial-mesenchymal spectrum with intermediate states exhibiting partial epithelial and mesenchymal traits. Although the fluid nature of EMT is essential for its function, the molecular mechanisms are poorly understood. We will identify the molecular players that achieve and maintain EMT plasticity. The project will provide research opportunities for trainees of all levels from postdoctoral scholars, grad students to undergrad students. In addition, the project will bring cell and developmental biology to high school classrooms by providing summer workshops for high school teachers from the Clark County School District.