Louisa Messenger (Environmental and Occupational Health) co-published a paper on "Genetic surveillance of insecticide resistance in African Anopheles populations to inform malaria vector control" in the journal Trends in Parasitology.
Insecticide resistance in malaria vector populations poses a major threat to malaria control, which relies largely on insecticidal interventions. Contemporary vector-control strategies focus on combatting resistance using multiple insecticides with differing modes of action within the mosquito. However, diverse genetic resistance mechanisms are present in vector populations, and continue to evolve. Knowledge of the spatial distribution of these genetic mechanisms, and how they impact the efficacy of different insecticidal products, is critical to inform intervention deployment decisions. In this paper, researchers developed a catalogue of genetic-resistance mechanisms in African malaria vectors that could guide molecular surveillance and highlight situations where intervention deployment has led to resistance evolution and spread, and identify challenges in understanding and mitigating the epidemiological impacts of resistance.