Hui Zhang and Hong Sun’s (both Chemistry and Biochemistry) biochemistry laboratories recently published a research article titled “The Assembly of Mammalian SWI/SNF Chromatin Remodeling Complexes is Regulated by Lysine-Methylation Dependent Proteolysis,” in Nature Communications. This research revealed for the first time how the mammalian SWI/SNF complexes are assembled and how these complexes cooperate with the pluripotent stem cell proteins such as SOX2 to regulate embryonic stem cells and mouse embryonic development. The mutations or loss of the SWI/SNF genes are associated with more than 20% of human cancers and many other human diseases.