With human longevity increasing, osteoporotic fracture is becoming a major public health issue. The purpose of this pilot study is to generate sufficient preliminary data for an R-level National Institutes of Health grant proposal to create a genomics-enhanced method for generating personalized reference values of bone mineral density for diagnosing osteoporosis in Caucasian women. This approach is expected to be much more accurate at predicting osteoporotic fractures than existing methods, and is likely to greatly contribute to the diagnosis, prevention, and cure of osteoporosis.